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KMID : 0604020140290020059
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Korean Journal of Critical Care Medicine
2014 Volume.29 No. 2 p.59 ~ p.63
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Severe Fever with Thrombocytopenia Syndrome
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Yoo Seung-Jin
Heo Sang-Taek
Lee Keun-Hwa
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Abstract
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Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease, caused by a novel species of Phlebovirusof Bunyaviridae family, in China, South Korea, and Japan. SFTS is primarily known as a tick-borne disease, and human-to-humantransmission is also possible in contact with infectious blood. Common clinical manifestations include fever, thrombocytopenia, andleukopenia as initial symptoms, and multiple organ dysfunction and failure manifest with disease progression. Whereas disease mortalityis reported to be 12% to 30% in China, a recent report of cumulative SFTS cases indicated 47% in Korea. Risk factors associatedwith SFTS were age, presence of neurologic disturbance, serum enzyme levels, and elevated concentrations of certain cytokines. Diagnosis of SFTS is based on viral isolation, viral identification by polymerase chain reaction, and serologic identification of specificimmunoglobulin G. Therapeutic guideline has not been formulated, but conservative management is the mainstream of treatmentto prevent disease progression and fatal complications.
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KEYWORD
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phlebovirus, severe fever with thrombocytopenia syndrome, Korea
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